The error 450 indicates that requested action not taken, the mailbox was unavailible at the remote end.
Here the server could not access the mailbox to deliver the message. This could be caused by a process on the remote server tyding up the mailbox or the remote mailbox could be correpted or the remote mailbox is stored on another server which is currently offline, or the network connection went down while sending or the remote mail server, does not want to access the mal from our server for some reason like blacklisting.
